Publications

  1. Optimization of cell growth on palmitoyl-hyaluronan knitted scaffolds developed for tissue engineering applications
    Sogorkova J, Zapotocky V, Cepa M, Stepankova V, Vagnerova H, Batova J, Pospisilova M, Betak J, Nesporova K, Hermannova M, Daro D, Duffy GP, Velebny V.
    J Biomed Mater Res A. 2018 Jan 29. doi: 10.1002/jbm.a.36353. [Epub ahead of print]

  2. Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibres from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling
    de Oliveira FCS, Olvera D, Sawkins MJ, Cryan SA, Kimmins SD, da Silva TE, Kelly DJ, Duffy GP, Kearney C, Heise A.
    Biomacromolecules. 2017 Dec 11;18(12):4292-4298. doi 10.1021/acs.biomac.7b01335. Epub 2017 Nov 14.

  3. Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo
    Roche P, Alekseeva T, Widaa A, Ryan A, Matsiko A, Walsh M, Duffy GP, O'Brien FJ.
    Stem Cells Transl Med. 2017 Oct;6(10):1894-1904. doi: 10.1002/sctm.16-0420.

  4. Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation
    Ryan AJ, O'Neill HS, Duffy GP, O'Brien FJ.
    Curr Opin Pharmacol. 2017 Aug 30;36:66-71. doi: 10.1016/j.coph.2017.07.013. [Epub ahead of print]

  5. Fabrication of biodegradable textile scaffold based on hydrophobized hyaluronic acid
    Zapotocky V, Pospisilova M, Janouchova K, Svadlak D, Batova J, Sogorkova J, Cepa M, Betak J, Stepankova V, Sulakova R, Kulhanek J, Pitucha T, Vranova J, Duffy GP, Velebny V.
    Int J Biol Macromol. 2017 Feb;95:903-909.

  6. Tissue Engineered Solutions for Intracardiac Septal Defects: A Large Step Forward in an Unmet Clinical Need
    Hameed A, Duffy GP, Hasan B, Fatimi SH.
    Ann Surg. 2017 Feb;265(2):e11-e12. doi: 10.1097/SLA.0000000000002060. No abstract available. PMID: 27811507

  7. A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro.
    Payne C, Dolan EB, O'Sullivan J, Cryan SA, Kelly HM.
    Drug Deliv Transl Res. 2017 Feb;7(1):132-146. doi: 10.1007/s13346-016-0347
    PMID: 27924469

  8. An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium.
    Curley CJ, Dolan EB, Cavanagh B, O'Sullivan J, Duffy GP, Murphy BP.
    J Biomed Mater Res B Appl Biomater. 2016 Oct 20. doi: 10.1002/jbm.b.33802. [Epub ahead of print]
    PMID: 27764526

  9. A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents.
    O'Neill HS, Herron CC, Hastings CL, Deckers R, Lopez Noriega A, Kelly HM, Hennink WE, McDonnell CO, O'Brien FJ, Ruiz-Hernández E, Duffy GP.
    Acta Biomater. 2017 Jan 15;48:110-119. doi: 10.1016/j.actbio.2016.10.001.
    PMID: 27773752

  10. Nanomedicines for advanced cancer treatments: Transitioning towards responsive systems.
    van Elk M, Murphy BP, Eufrásio-da-Silva T, O'Reilly DP, Vermonden T, Hennink WE, Duffy GP, Ruiz-Hernández E.
    Int J Pharm. 2016 Dec 30;515(1-2):132-164. doi: 10.1016/j.ijpharm.2016.10.013. Review.
    PMID: 27725268

  11. A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation.
    O'Neill HS, O'Sullivan J, Porteous N, Ruiz Hernandez E, Kelly HM, O'Brien FJ, Duffy GP.
    J Tissue Eng Regen Med. 2016 Dec 12. doi: 10.1002/term.2392. [Epub ahead of print]
    PMID: 27943590

  12. Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives.
    Raftery RM, Walsh DP, Castaño IM, Heise A, Duffy GP, Cryan SA, O'Brien FJ.
    Adv Mater. 2016 Jul;28(27):5447-69. doi: 10.1002/adma.201505088. Epub 2016 Feb 3.
    PMID: 26840618

  13. Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives.
    O'Neill HS, Gallagher LB, O'Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O'Dwyer J, Payne C, O'Reilly D, Ruiz-Hernandez E, Roche ET, O'Brien FJ, Cryan SA, Kelly H, Murphy B, Duffy GP.
    Adv Mater. 2016 Jul;28(27):5648-61. doi: 10.1002/adma.201505349. Epub 2016 Feb 3.
    PMID: 26840955

  14. Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis.
    Mencía Castaño I, Curtin CM, Duffy GP, O'Brien FJ.
    Sci Rep. 2016 Jun 14;6:27941. doi: 10.1038/srep27941.
    PMID: 27297802

  15. Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types.
    Murphy CM, Duffy GP, Schindeler A, O'Brien FJ.
    J Biomed Mater Res A. 2016 Jan;104(1):291-304. doi: 10.1002/jbm.a.35567. Epub 2015 Oct 1.
    PMID: 26386362

  16. Form and function in regenerative medicine: introduction.
    O'Brien FJ, Duffy GP.
    J Anat. 2015 Dec;227(6):705-6. doi: 10.1111/joa.12401. No abstract available.
    PMID: 26768088

  17. Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells.
    Lloyd-Griffith C, Duffy GP, O'Brien FJ.
    J Anat. 2015 Dec;227(6):767-80. doi: 10.1111/joa.12283. Epub 2015 Mar 31.
    PMID: 25833670

  18. The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation.
    Mulcahy LE, Curtin CM, McCoy RJ, O'Brien FJ, Taylor D, Lee TC, Duffy GP.
    Eur Cell Mater. 2015 Nov 27;30:271-81.
    PMID: 26614482 Free Article

  19. The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation.
    Lloyd-Griffith C, McFadden TM, Duffy GP, Unger RE, Kirkpatrick CJ, O'Brien FJ.
    Acta Biomater. 2015 Oct;26:263-73. doi: 10.1016/j.actbio.2015.08.030. Epub 2015 Aug 20.
    PMID: 26300337

  20. Spatiotemporal delivery of small molecule therapeutics using a thermosensitive liposome loaded hydrogel.
    O'Neill H, Herron C, Hastings C, Lopez-Noriega A, Kelly HM, O'Brien FJ, Ruiz-Hernandez E, Duffy GP.
    J Control Release. 2015 Sep 10;213:e28-9. doi: 10.1016/j.jconrel.2015.05.044. Epub 2015 Aug 19. No abstract available.
    PMID: 27005143

  21. Drug and cell delivery for cardiac regeneration.
    Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP.
    Adv Drug Deliv Rev. 2015 Apr;84:85-106. doi: 10.1016/j.addr.2014.08.006. Epub 2014 Aug 27. Review.
    PMID: 25172834 Free Article

  22. A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells.
    Mencía Castaño I, Curtin CM, Shaw G, Murphy JM, Duffy GP, O'Brien FJ.
    J Control Release. 2015 Feb 28;200:42-51. doi: 10.1016/j.jconrel.2014.12.034. Epub 2014 Dec 28.
    PMID: 25550154

  23. Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering.
    Quinlan E, López-Noriega A, Thompson E, Kelly HM, Cryan SA, O'Brien FJ.
    J Control Release. 2015 Jan 28;198:71-9. doi: 10.1016/j.jconrel.2014.11.021. Epub 2014 Dec 4.
    PMID: 25481441

  24. Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.
    Curtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ.
    Adv Healthc Mater. 2015 Jan 28;4(2):223-7. doi: 10.1002/adhm.201400397. Epub 2014 Aug 13.
    PMID: 25125073

  25. An experimental investigation of the effect of mechanical and biochemical stimuli on cell migration within a decellularized vascular construct.
    Sheridan WS, Ryan AJ, Duffy GP, O'Brien FJ, Murphy BP.
    Ann Biomed Eng. 2014 Oct;42(10):2029-38. doi: 10.1007/s10439-014-1063-z. Epub 2014 Jul 2.
    PMID: 24986334

  26. Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.
    Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ.
    Biomaterials. 2014 Aug;35(25):6850-8. doi: 10.1016/j.biomaterials.2014.04.114. Epub 2014 May 23.
    PMID: 24862441 Free PMC Article

  27. Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy.
    López-Noriega A, Hastings CL, Ozbakir B, O'Donnell KE, O'Brien FJ, Storm G, Hennink WE, Duffy GP, Ruiz-Hernández E.
    Adv Healthc Mater. 2014 Jun;3(6):854-9. doi: 10.1002/adhm.201300649. Epub 2014 Jan 16.
    PMID: 24436226

  28. The application of a thermoresponsive chitosan/β-GP gel to enhance cell repopulation of decellularized vascular scaffolds.
    Sheridan WS, Grant OB, Duffy GP, Murphy BP.
    J Biomed Mater Res B Appl Biomater. 2014 Nov;102(8):1700-10. doi: 10.1002/jbm.b.33138. Epub 2014 Mar 25.
    PMID: 24664907

  29. Enhanced delivery of microRNA mimics to cardiomyocytes using ultrasound responsive microbubbles reverses hypertrophy in an in-vitro model.
    Gill SL, O'Neill H, McCoy RJ, Logeswaran S, O'Brien F, Stanton A, Kelly H, Duffy GP.
    Technol Health Care. 2014;22(1):37-51. doi: 10.3233/THC-130772.
    PMID: 24398813

  30. Mesenchymal stem cells to augment therapeutic angiogenesis in hind-limb ischemia models: how important is their source?
    Duffy GP, Herron CC.
    Stem Cell Res Ther. 2013;4(5):131.
    PMID: 24156359 Free PMC Article

  31. The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo.
    McFadden TM, Duffy GP, Allen AB, Stevens HY, Schwarzmaier SM, Plesnila N, Murphy JM, Barry FP, Guldberg RE, O'Brien FJ.
    Acta Biomater. 2013 Dec;9(12):9303-16. doi: 10.1016/j.actbio.2013.08.014. Epub 2013 Aug 17.
    PMID: 23958783

  32. Optimum parameters for freeze-drying decellularized arterial scaffolds.
    Sheridan WS, Duffy GP, Murphy BP.
    Tissue Eng Part C Methods. 2013 Dec;19(12):981-90. doi: 10.1089/ten.TEC.2012.0741. Epub 2013 Jun 25.
    PMID: 23614758 Free PMC Article

  33. Orchestrating osteogenic differentiation of mesenchymal stem cells--identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic role.
    McCoy RJ, Widaa A, Watters KM, Wuerstle M, Stallings RL, Duffy GP, O'Brien FJ.
    Stem Cells. 2013 Nov;31(11):2420-31. doi: 10.1002/stem.1482.
    PMID: 23897668 Free Article

  34. Encapsulation of cardiac stem cells in superoxide dismutase-loaded alginate prevents doxorubicin-mediated toxicity.
    Liu TC, Ismail S, Brennan O, Hastings C, Duffy GP.
    J Tissue Eng Regen Med. 2013 Apr;7(4):302-11. doi: 10.1002/term.523. Epub 2011 Dec 30.
    PMID: 22213742

  35. Non-viral gene-activated matrices: next generation constructs for bone repair.
    Tierney EG, Duffy GP, Cryan SA, Curtin CM, O'Brien FJ.
    Organogenesis. 2013 Jan-Mar;9(1):22-8. doi: 10.4161/org.24329. Epub 2013 Jan 1.
    PMID: 23538777 Free PMC Article

  36. High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix.
    Tierney EG, McSorley K, Hastings CL, Cryan SA, O'Brien T, Murphy MJ, Barry FP, O'Brien FJ, Duffy GP.
    J Control Release. 2013 Feb 10;165(3):173-82. doi: 10.1016/j.jconrel.2012.11.013. Epub 2012 Nov 29.
    PMID: 23201622

  37. Supramolecular hydrogels with reverse thermal gelation properties from (oligo)tyrosine containing block copolymers.
    Huang J, Hastings CL, Duffy GP, Kelly HM, Raeburn J, Adams DJ, Heise A.
    Biomacromolecules. 2013 Jan 14;14(1):200-6. doi: 10.1021/bm301629f. Epub 2012 Dec 7.
    PMID: 23190093

  38. Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia.
    Hastings CL, Kelly HM, Murphy MJ, Barry FP, O'Brien FJ, Duffy GP.
    J Control Release. 2012 Jul 10;161(1):73-80. doi: 10.1016/j.jconrel.2012.04.033. Epub 2012 Apr 27.
    PMID: 22562065

  39. Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering.
    Sheridan WS, Duffy GP, Murphy BP.
    J Mech Behav Biomed Mater. 2012 Apr;8:58-70. doi: 10.1016/j.jmbbm.2011.12.003. Epub 2011 Dec 27.
    PMID: 22402154

  40. Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation.
    Curtin CM, Cunniffe GM, Lyons FG, Bessho K, Dickson GR, Duffy GP, O'Brien FJ.
    Adv Mater. 2012 Feb 7;24(6):749-54. doi: 10.1002/adma.201103828. Epub 2012 Jan 2.
    PMID: 22213347

  41. The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds.
    Tierney EG, Duffy GP, Hibbitts AJ, Cryan SA, O'Brien FJ.
    J Control Release. 2012 Mar 10;158(2):304-11. doi: 10.1016/j.jconrel.2011.11.026. Epub 2011 Nov 27.
    PMID: 22138069

  42. Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression.
    Haugh MG, Meyer EG, Thorpe SD, Vinardell T, Duffy GP, Kelly DJ.
    Tissue Eng Part A. 2011 Dec;17(23-24):3085-93. doi: 10.1089/ten.tea.2011.0198. Epub 2011 Aug 26.
    PMID: 21870950

  43. RANKL and OPG activity is regulated by injury size in networks of osteocyte-like cells.
    Mulcahy LE, Taylor D, Lee TC, Duffy GP.
    Bone. 2011 Feb;48(2):182-8. doi: 10.1016/j.bone.2010.09.014. Epub 2010 Sep 18.
    PMID: 20854946

  44. Towards in vitro vascularisation of collagen-GAG scaffolds.
    Duffy GP, McFadden TM, Byrne EM, Gill SL, Farrell E, O'Brien FJ.
    Eur Cell Mater. 2011 Jan 12;21:15-30.
    PMID: 21225592 Free Article

  45. The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs.
    Lyons FG, Al-Munajjed AA, Kieran SM, Toner ME, Murphy CM, Duffy GP, O'Brien FJ.
    Biomaterials. 2010 Dec;31(35):9232-43. doi: 10.1016/j.biomaterials.2010.08.056. Epub 2010 Sep 22.
    PMID: 20863559

  46. Mesenchymal stem cells overexpressing ephrin-b2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential.
    Duffy GP, D'Arcy S, Ahsan T, Nerem RM, O'Brien T, Barry F.
    Tissue Eng Part A. 2010 Sep;16(9):2755-68. doi: 10.1089/ten.tea.2009.0623.
    PMID: 20491587

  47. Bone marrow-derived mesenchymal stem cells promote angiogenic processes in a time- and dose-dependent manner in vitro.
    Duffy GP, Ahsan T, O'Brien T, Barry F, Nerem RM.
    Tissue Eng Part A. 2009 Sep;15(9):2459-70. doi: 10.1089/ten.TEA.2008.0341.
    PMID: 19327020

  48. Bioadhesive, rheological, lubricant and other aspects of an oral gel formulation intended for the treatment of xerostomia.
    Kelly HM, Deasy PB, Busquet M, Torrance AA.
    Int J Pharm. 2004 Jul 8;278(2):391-406.
    PMID: 15196643

  49. Formulation and preliminary in vivo dog studies of a novel drug delivery system for the treatment of periodontitis.
    Kelly HM, Deasy PB, Ziaka E, Claffey N.
    Int J Pharm. 2004 Apr 15;274(1-2):167-83.
    PMID: 15072793

 

Innovations

  1. Mesenchymal stem cell for promoting neovascularisation.
    Patent no: US 8617883 B2
    Inventors: Duffy G.P., Barry, F., O'Brien, T.
    Publication date 31st Dec 2013.